PATTERNS & PHENOTYPES Expression of Stem Cell Pluripotency Factors During Regeneration in Newts

نویسندگان

  • Nobuyasu Maki
  • Rinako Suetsugu-Maki
  • Hiroshi Tarui
  • Kiyokazu Agata
  • Katia Del Rio-Tsonis
  • Panagiotis A. Tsonis
چکیده

In this study, we present data indicating that mammalian stem cell pluripotency-inducing factors are expressed during lens and limb regeneration in newts. The apparent expression even in intact tissues and the ensued regulation during regeneration raises the possibility that these factors might regulate tissuespecific reprogramming and regeneration. Furthermore, these factors should enable us to understand the similarities and differences between animal regeneration in the newt and stem cell strategies in mammals. Developmental Dynamics 238:1613–1616, 2009. © 2009 Wiley-Liss, Inc.

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Expression of stem cell pluripotency factors during regeneration in newts.

In this study, we present data indicating that mammalian stem cell pluripotency-inducing factors are expressed during lens and limb regeneration in newts. The apparent expression even in intact tissues and the ensued regulation during regeneration raises the possibility that these factors might regulate tissue-specific reprogramming and regeneration. Furthermore, these factors should enable us ...

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تاریخ انتشار 2009